Molgora B, Bateman R, Sweeney G, Finger D, Dimler T, Effros RB, Valenzuela HF, Cell Journal. 2013 January 14: ISSN 2073-4409

This human study showed that TA-65MD nutritional supplementation increased telomerase activity and proliferation in human CD4 and CD8 T cells. It highlights the importance of telomerase activation in age-related pathologies.

Methods: CD4 and CD8 T cells from healthy subjects were treated with TA-65MD. Telomerase activity was measured in these samples 72 hours after the initial stimulation. The process was repeated 18-21 days later for the second stimulation.

Findings, Method of Action: TA-65 increased telomerase activity in T cells from all subjects in both primary and secondary stimulation. The results suggest that TA-65 may utilize the MAPK pathway to activate telomerase. This result was observed in both CD4 and CD8 T cells, but was most pronounced in CD8 T cells in the second stimulation.

Study Results, Health Effects: This study demonstrates that during acute viral infection, TA-65 rapidly induces telomerase activity, which other studies have linked to enhanced health and longevity markers.

The most important findings from this preliminary study are:

• Clinical conditions that require enhancement of T cell telomerase activity should benefit from TA-65

• Acute viral infection regimens may benefit from the addition of TA-65

Study Results, Safety: No adverse side effects, interactions, or any other negative effects were reported during this study, nor were any negative results reported from any other studies related to TA-65. No uncontrolled cell growth was observed in this study.