Salvadore L, Singaravelu G, Harry CB, Fromm P, Suram A, Rafael JM.
TA-65 is a dietary supplement based on an improved formulation of a small-molecule telomerase activator discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on changes in telomere length (TL) in a 1-year randomized, double-blind, placebo-controlled study of TA-65.
The study was conducted in 97 relatively healthy CMV-positive subjects aged 53-87 years. Subjects taking the low dose of TA-65 (250 U) had a significant increase in TL over the 12-month period compared with the placebo group (530±180 BP; p = 0.005), while subjects in the placebo group had a significant decrease in TL (290±100 BP; p = 0.01). The high dose of TA-65 (1000 U) showed a trend toward improved TL compared with the placebo group; however, these improvements did not reach statistical significance. The median and 20th percentile TL changes in TL were similar in the low dose group. These findings suggest that TA-65 can extend telomeres in a statistically and potentially clinically significant manner.
Study participants: 97 men and women (53-87 years old)
Study time: 12 months
First study to show statistically significant (p
As expected, the placebo group showed a decrease in telomere length
Median telomere length in the placebo group | |
| Median telomere length | 290±100 bps |
| 20th percentile telomere length | 170±50 basis points |
The group taking one TA-65 capsule (250 units) per day showed an increase in telomere length.
The median telomere length increased in the TA-65 group | |
| Median telomere length | 533 180 basis points |
| 20th percentile telomere length | 270±90 basis points |
Published in Rejuvenation Research, a PubMed-indexed and peer-reviewed journal — [PMID: 26950204 ]