A new study published by the University of Connecticut in the latest issue of Contemporary Drug Design suggests that daily use of telomerase activator TA-65 can provide protection against metabolic abnormalities associated with metabolic syndrome.

Observation

Just like shoulder straps (plastic tips at the end of shoelaces to prevent wear and tear), telomeres are the caps at the end of our DNA strands, protecting our chromosomes from damage. When telomeres become very short, cells begin to die. Scientists know that an enzyme in the human body, telomerase, can increase the length of these telomeres. Clinical observers want to know if activating telomerase, thereby prolonging telomeres, will have beneficial effects on patients with metabolic syndrome.

Assumption

Previous studies have shown that commercially available nutritional supplements TA-65 can activate human telomerase and increase telomere length. This latest study aims to demonstrate the impact of these extended telomeres on high-risk subjects by evaluating the impact of TA-65 on patients with metabolic syndrome.

Method

This is a crossover study in which 40 screened and blood tested males and females aged between 32 and 70 took TA-65 supplementation capsules or placebo capsules daily for 12 weeks. Then, after a 3-week washout period, they were switched to alternative capsules for 12 weeks.

The subjects underwent examination and thorough testing for symptoms of metabolic syndrome:

Centripetal obesity

high blood pressure

high blood pressure

Hyperglycemia

inflammation

High and low-density lipoprotein cholesterol levels

This is a double-blind, randomized study, which means that neither the subjects nor the researchers know which participants took TA-65 capsules and which participants took placebo capsules. During the research process, there were no other lifestyle changes.

This study indicates that TA-65 improves the following biomarkers:

Lower body mass index (BMI) and waist circumference

Reduce the ratio of low-density lipoprotein ("bad") cholesterol to high-density lipoprotein ("good") cholesterol

High levels of "good" cholesterol from high-density lipoprotein (proven to prevent inflammation)

Reduce plasma TNF (tumor necrosis factor)

CRP liver enzyme levels are low (indicating inflammation)

Conclusion

Within 12 weeks of taking the TA-65 supplement, study participants showed improvement in symptoms of metabolic syndrome. It has been determined that shifting towards a healthier diet can prevent further damage caused by high cholesterol, inflammation, and free radicals. Therefore, combining TA-65 supplements with dietary changes seems to be a good alternative to improving symptoms of metabolic syndrome and reducing future health complications in this high-risk population.

For detailed information on topic testing and methods, you can read all the research from the University of Connecticut.