Patent Owner: Sobei Genomics, Inc
Technical fields:
The present invention relates to the field of NAD+ applications, and in particular to the application of NAD+ anti-aging compositions.
Technical Background:
With the improvement of people's living standards and the advancement of medical technology, anti-aging has become a focus of people's attention. In recent years, with the in-depth study of the mechanism of cell aging, the application of NAD+ (nicotinamide adenine dinucleotide) in the field of anti-aging has gradually attracted attention. NAD+ is an important coenzyme in cells, participating in a variety of biochemical reactions, and plays an important role in maintaining the normal function of cells. Studies have shown that with the increase of age, the level of NAD+ in cells gradually decreases, leading to the decline of cell function and thus inducing aging. Therefore, increasing the level of NAD+ in cells has become an important direction of anti-aging research.
However, there are many types of NAD+ anti-aging products on the market with varying quality, and most products only focus on increasing NAD+ levels while ignoring other aging-related factors in cells. Therefore, it is of great practical significance to develop a multifunctional anti-aging composition that can both increase NAD+ levels in cells and comprehensively regulate cell aging.
Invention content:
The purpose of the present invention is to provide an application of NAD+ anti-aging composition, aiming to solve the problems of existing anti-aging drugs or health products such as poor efficacy, high cost, unstable product quality, and toxic side effects.
Activates 9 longevity factors, repairs damaged cells, provides energy to mitochondria, and extends telomere length.
NAD can promote the production of red blood cells in the human body, and can improve anemia when used together with chemotherapy. The enzyme can prevent normal tissue cells from chemical and radiation damage and apoptosis. H22 cells treated with NAD have strong immunogenicity and can stimulate the body to produce specific anti-tumor immunity. They are a good tumor vaccine, and their anti-tumor effect is mediated by the HSP70 protein expressed on the tumor cell membrane. NAD has the effect of strengthening the gastric mucus barrier and promoting ulcer healing. NAD has antioxidant and anti-aging effects, protects cell membranes, prevents cell necrosis and mutation, and prevents liver fibrosis.
At present, nicotinamide adenine dinucleotide (NAD+, coenzyme I, the active form of vitamin B3) is one of the basic life molecules necessary for cells. NAD+ and its corresponding reduced form NADH participate in various redox processes (such as glycolysis, citric acid cycle, oxidative phosphorylation, etc.) as proton acceptors or donors. In addition, in non-redox processes such as cell growth, differentiation, and regulation, NAD+ participates in the modification of macromolecules such as nucleic acids and proteins as a reaction substrate, such as DNA and RNA modification involving NAD+, NAD+-dependent histone deacetylation, and NAD+-dependent ubiquitination. NAD+ is composed of adenosine monophosphate (AMP) and nicotinamide mononucleotide (NMN). In organisms, the synthesis of NAD+ includes de novo synthesis pathways and salvage synthesis pathways using nicotinamide precursors. Two de novo synthesis pathways of NAD+ have been discovered: the aspartate pathway (Pathway I) and the tryptophan-kynuric acid pathway (Pathway II). The NAD+ used in the present invention does not contain organic solvent residues, does not have chirality problems, produces the same type of NAD+ as in the body, and has cost advantages. Then, conventional methods in the field of medicine and health products are used to prepare various dosage forms with pharmaceutically acceptable excipients.
Preferably, the NAD+ dosage form is an oral preparation and/or a parenteral dosage form.
The oral preparation is selected from any one or more of tablets, powders, capsules, granules, pills, suspensions, syrups, mixtures, powders and pellets; the enteral administration dosage form is selected from any one or more of injections, inhalants, patches, suppositories and ointments.
Advantages of invention:
NAD+ exists in every cell of our body. It is a key metabolite and coenzyme in multiple metabolic pathways, mediating and participating in various biological processes. More than 300 enzymes rely on NAD+ to work.
Simply put, NAD+ is essential for maintaining overall health and balance. Metabolism, redox, DNA maintenance and repair, gene stability, epigenetic regulation, etc. all require the participation of NAD+.
At the same time, with the synergistic effect of auxiliary materials, it has a good effect of repairing DNA and anti-aging, and the structure of each component is stable, so the corresponding products are not easy to deteriorate or be damaged after being made. Each component is safe and has no adverse reaction to the human body.
Product efficacy:
(1) Anti-aging: improve sleep, enhance memory, anti-aging, and delay aging;
(2) DNA repair: suitable for patients undergoing chemotherapy and radiation exposure;
(3) Diabetes: It can effectively prevent type 2 diabetes caused by diet and young age;
(4) Improve endurance: Promote fat decomposition, enhance exercise endurance, enhance skeletal muscle formation and mitochondrial oxidative metabolism;
(5) Neurocognition: It can reduce brain cell death and oxidative stress, further proving the protective effect of NMN on the nervous system. NMN restores mitochondrial function, restores AD's cognitive ability, and restores cognitive impairment.
(6) Cardiovascular: Increases cardiac NDA+ levels, protects the heart, reduces vascular oxidation, improves arterial aging, and reduces myocardial inflammation;
(7) Sobering up and protecting the liver: promoting alcohol metabolism;
(8) Protect vision: prevent photoreceptor cell degeneration and restore vision, saving retinal disorders;
(9) Hearing protection: Methods to increase NDA+ levels in ear neurons and tissues can provide protection against hearing loss caused by trauma.
Preparation Method:
The present invention provides a method for preparing a NAD+ anti-aging composition. The composition comprises NADH and B12. NAD+ precursors can be converted into NAD+ in cells, thereby increasing the level of NAD+ in cells. Natural plant extracts are rich in a variety of antioxidant substances, which can scavenge free radicals and protect cells from oxidative damage.
The preparation method is as follows: NADH and B12 are mixed in a certain proportion, an appropriate amount of solvent is added to dissolve, and then filtering, concentrating and other steps are performed to finally obtain the NAD+ anti-aging composition. The composition can be taken orally or applied externally, and is convenient to use.
The NAD+ anti-aging composition of the present invention has multiple functions such as increasing the NAD+ level in cells, promoting cell metabolism, and removing free radicals. It can effectively delay the aging process, improve skin quality, and enhance physical health. At the same time, the composition uses natural plant extracts, has the advantages of high safety and few side effects, and is an ideal anti-aging product.
In summary, the application of NAD+ anti-aging composition in the present invention solves the technical defects of the existing anti-aging products that are difficult to take into account good anti-aging effects, harmlessness to the human body and stable product quality, and can significantly extend human life. AMPK activates longevity factors, repairs damaged cells, provides energy for mitochondria, and prolongs telomere length.